Wall teichoic acid protects Staphylococcus aureus against 2 antimicrobial fatty acids from human skin
نویسندگان
چکیده
4 5 6 Thomas Kohler, Christopher Weidenmaier and Andreas Peschel 7 8 9 10 11 1 Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene 12 Institute, University of Tübingen, Tübingen, Germany 13 2 Brigham and Womens Hospital, Department of Medicine, Harvard Medical School, 14 Boston, USA 15 16 17 18 19 Correspondence should be addressed to A.P. 20 E-mail [email protected] 21 Phone (+49)-7071-2981515 22 Fax (+49)-7071-293435 23 24 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00221-09 JB Accepts, published online ahead of print on 8 May 2009
منابع مشابه
Wall teichoic acid protects Staphylococcus aureus against antimicrobial fatty acids from human skin.
Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.
متن کاملWall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes.
OBJECTIVES Polyanionic polymers, including lipoteichoic acid and wall teichoic acid, are important determinants of the charged character of the staphylococcal cell wall. This study was designed to investigate the extent to which teichoic acid contributes to protection from anionic azo dyes and to identify barriers to drug penetration for development of new antibiotics for multidrug-resistant St...
متن کاملAlanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model.
Staphylococcus aureus is inherently resistant to cationic antimicrobial peptides because of alanylation of cell envelope teichoic acids. To test the effect of alanylated teichoic acids on virulence and host defense mediated by Toll-like receptor 2 (TLR2), wild-type (wt) S. aureus ATCC35556 (S.a.113) and its isogenic mutant expressing unalanylated teichoic acids (dlt(-)) were compared in a tissu...
متن کاملAn accessory wall teichoic acid glycosyltransferase protects Staphylococcus aureus from the lytic activity of Podoviridae
Many Staphylococcus aureus have lost a major genetic barrier against phage infection, termed clustered regularly interspaced palindromic repeats (CRISPR/cas). Hence, S. aureus strains frequently exchange genetic material via phage-mediated horizontal gene transfer events, but, in turn, are vulnerable in particular to lytic phages. Here, a novel strategy of S. aureus is described, which protects...
متن کاملInactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides.
Positively charged antimicrobial peptides with membrane-damaging activity are produced by animals and humans as components of their innate immunity against bacterial infections and also by many bacteria to inhibit competing microorganisms. Staphylococcus aureus and Staphylococcus xylosus, which tolerate high concentrations of several antimicrobial peptides, were mutagenized to identify genes re...
متن کامل